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Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages
Resistance to drugs used to treat tuberculosis disease (TB) continues to remain a public health burden, with missense point mutations in the underlying Mycobacterium tuberculosis bacteria described for nearly all anti-TB drugs. The post-genomics era along with advances in computational and structura...
Autores principales: | Tunstall, Tanushree, Phelan, Jody, Eccleston, Charlotte, Clark, Taane G., Furnham, Nicholas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372558/ https://www.ncbi.nlm.nih.gov/pubmed/34422898 http://dx.doi.org/10.3389/fmolb.2021.619403 |
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