Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L

SARS-CoV-2 requires serine protease, transmembrane serine protease 2 (TMPRSS2), and cysteine proteases, cathepsins B, L (CTSB/L) for entry into host cells. These host proteases activate the spike protein and enable SARS-CoV-2 entry. We herein performed genomic-guided gene set enrichment analysis (GS...

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Detalles Bibliográficos
Autores principales: Prasad, Kartikay, AlOmar, Suliman Yousef, Almuqri, Eman Abdullah, Rudayni, Hassan Ahmed, Kumar, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372896/
https://www.ncbi.nlm.nih.gov/pubmed/34407143
http://dx.doi.org/10.1371/journal.pone.0256141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372896/
https://www.ncbi.nlm.nih.gov/pubmed/34407143
http://dx.doi.org/10.1371/journal.pone.0256141

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