Motif WFYY of human PrimPol is crucial to stabilize the incoming 3′-nucleotide during replication fork restart

PrimPol is the second primase in human cells, the first with the ability to start DNA chains with dNTPs. PrimPol contributes to DNA damage tolerance by restarting DNA synthesis beyond stalling lesions, acting as a TLS primase. Multiple alignment of eukaryotic PrimPols allowed us to identify a highly...

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Detalles Bibliográficos
Autores principales: Calvo, Patricia A, Martínez-Jiménez, María I, Díaz, Marcos, Stojkovic, Gorazd, Kasho, Kazutoshi, Guerra, Susana, Wanrooij, Sjoerd, Méndez, Juan, Blanco, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373064/
https://www.ncbi.nlm.nih.gov/pubmed/34302490
http://dx.doi.org/10.1093/nar/gkab634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373064/
https://www.ncbi.nlm.nih.gov/pubmed/34302490
http://dx.doi.org/10.1093/nar/gkab634

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