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Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction
Newly synthesized mRNA is translated during its export through the nuclear pore complex, when its 5′-cap structure is still bound by the nuclear cap-binding complex (CBC), a heterodimer of cap-binding protein (CBP) 80 and CBP20. Despite its critical role in mRNA surveillance, the mechanism by which...
Autores principales: | Park, Yeonkyoung, Park, Joori, Hwang, Hyun Jung, Kim, Leehyeon, Jeong, Kwon, Song, Hyun Kyu, Rufener, Simone C, Mühlemann, Oliver, Kim, Yoon Ki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373075/ https://www.ncbi.nlm.nih.gov/pubmed/34232997 http://dx.doi.org/10.1093/nar/gkab579 |
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