Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

Phosphorothioate (PS) modified antisense oligonucleotide (ASO) drugs can trigger RNase H1 cleavage of cellular target RNAs to modulate gene expression. Internalized PS-ASOs must be released from membraned endosomal organelles, a rate limiting step that is not well understood. Recently we found that...

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Detalles Bibliográficos
Autores principales: Liang, Xue-Hai, Nichols, Joshua G, De Hoyos, Cheryl Li, Sun, Hong, Zhang, Lingdi, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373082/
https://www.ncbi.nlm.nih.gov/pubmed/34244781
http://dx.doi.org/10.1093/nar/gkab599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373082/
https://www.ncbi.nlm.nih.gov/pubmed/34244781
http://dx.doi.org/10.1093/nar/gkab599

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