Cargando…

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

Phosphorothioate (PS) modified antisense oligonucleotide (ASO) drugs can trigger RNase H1 cleavage of cellular target RNAs to modulate gene expression. Internalized PS-ASOs must be released from membraned endosomal organelles, a rate limiting step that is not well understood. Recently we found that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Xue-Hai, Nichols, Joshua G, De Hoyos, Cheryl Li, Sun, Hong, Zhang, Lingdi, Crooke, Stanley T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373082/ https://www.ncbi.nlm.nih.gov/pubmed/34244781 http://dx.doi.org/10.1093/nar/gkab599

Ejemplares similares

Perinuclear positioning of endosomes can affect PS-ASO activities
por: Liang, Xue-hai, et al.
Publicado: (2021)

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes
por: Liang, Xue-hai, et al.
Publicado: (2020)

RNA modifications can affect RNase H1-mediated PS-ASO activity
por: Doxtader Lacy, Katelyn A., et al.
Publicado: (2022)

Insights into innate immune activation via PS-ASO–protein–TLR9 interactions
por: Pollak, Adam J, et al.
Publicado: (2022)

Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity
por: Liang, Xue-hai, et al.
Publicado: (2020)

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs
por: Zhang, Lingdi, et al.
Publicado: (2022)

Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1
por: Vickers, Timothy A, et al.
Publicado: (2019)

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs
por: Vasquez, Guillermo, et al.
Publicado: (2021)

Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides
por: Wang, Shiyu, et al.
Publicado: (2017)

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes
Publicado: (1992)

Mutants in trs120 disrupt traffic from the early endosome to the late Golgi
por: Cai, Huaqing, et al.
Publicado: (2005)

Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval
por: Hirst, Jennifer, et al.
Publicado: (2018)

When I was at Aso-Mountain
Publicado: (1993)

NanoSIMS Imaging Reveals the Impact of Ligand-ASO Conjugate Stability on ASO Subcellular Distribution
por: Kay, Emma, et al.
Publicado: (2022)

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
por: Migawa, Michael T, et al.
Publicado: (2019)

Determinants of [Cl(−)] in recycling and late endosomes and Golgi complex measured using fluorescent ligands
por: Sonawane, N.D., et al.
Publicado: (2003)

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function
por: Reverter, Meritxell, et al.
Publicado: (2011)

Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
por: Sobo, Komla, et al.
Publicado: (2007)

Endosomes and Golgi vesicles in adsorptive and fluid phase endocytosis
Publicado: (1984)

Individualized ASO therapy for rare diseases
Publicado: (2023)

Imaging and Quantitation Techniques for Tracking Cargo along Endosome-to-Golgi Transport Pathways
por: Chia, Pei Zhi Cheryl, et al.
Publicado: (2013)

ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus
por: Nakai, Waka, et al.
Publicado: (2013)

A Selective Transport Route from Golgi to Late Endosomes That Requires the Yeast Gga Proteins
por: Black, Michael W., et al.
Publicado: (2000)

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver
por: Miller, Colton M., et al.
Publicado: (2016)

Rab11 Regulates the Compartmentalization of Early Endosomes Required for Efficient Transport from Early Endosomes to the Trans-Golgi Network
por: Wilcke, Mona, et al.
Publicado: (2000)

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
por: Seaman, Matthew N.J.
Publicado: (2004)

Glucose regulates clathrin adaptors at the trans-Golgi network and endosomes
por: Aoh, Quyen L., et al.
Publicado: (2011)

Membrane Delivery to the Yeast Autophagosome from the Golgi–Endosomal System
por: Ohashi, Yohei, et al.
Publicado: (2010)

Recycling endosomes associate with Golgi stacks in sea urchin embryos
por: Fujii, Syara, et al.
Publicado: (2020)

RbH(2)AsO(4)
por: Stöger, Berthold
Publicado: (2013)

ASO Author Reflections: 30 Years of Esophagectomy
por: Phillips, A. W., et al.
Publicado: (2021)

Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes
por: Lund, Viktor Karlovich, et al.
Publicado: (2018)

Late endosomes uproot focal adhesions
por: Short, Ben
Publicado: (2014)

Biomechanics and Thermodynamics of Nanoparticle Interactions with Plasma and Endosomal Membrane Lipids in Cellular Uptake and Endosomal Escape
por: Peetla, Chiranjeevi, et al.
Publicado: (2014)

Energy metabolism regulates clathrin adaptors at the trans-Golgi network and endosomes
por: Aoh, Quyen L., et al.
Publicado: (2013)

SMAP2 Regulates Retrograde Transport from Recycling Endosomes to the Golgi
por: Matsudaira, Tatsuyuki, et al.
Publicado: (2013)

Evidence for a Golgi-to-Endosome Protein Sorting Pathway in Plasmodium falciparum
por: Krai, Priscilla, et al.
Publicado: (2014)

Rab5-mediated endosome formation is regulated at the trans-Golgi network
por: Nagano, Makoto, et al.
Publicado: (2019)

Convergence of secretory, endosomal, and autophagic routes in trans-Golgi–associated lysosomes
por: Zhou, Lingjian, et al.
Publicado: (2022)

An intranasal ASO therapeutic targeting SARS-CoV-2
por: Zhu, Chi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uchs8kme1vt7us0rrgm5080lnv