Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase

DNMT3A/3L heterotetramers contain two active centers binding CpG sites at 12 bp distance, however their interaction with DNA not containing this feature is unclear. Using randomized substrates, we observed preferential co-methylation of CpG sites with 6, 9 and 12 bp spacing by DNMT3A and DNMT3A/3L....

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Detalles Bibliográficos
Autores principales: Emperle, Max, Bangalore, Disha M, Adam, Sabrina, Kunert, Stefan, Heil, Hannah S, Heinze, Katrin G, Bashtrykov, Pavel, Tessmer, Ingrid, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373138/
https://www.ncbi.nlm.nih.gov/pubmed/34289056
http://dx.doi.org/10.1093/nar/gkab600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373138/
https://www.ncbi.nlm.nih.gov/pubmed/34289056
http://dx.doi.org/10.1093/nar/gkab600

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