Guanidine-II aptamer conformations and ligand binding modes through the lens of molecular simulation

Regulation of gene expression via riboswitches is a widespread mechanism in bacteria. Here, we investigate ligand binding of a member of the guanidine sensing riboswitch family, the guanidine-II riboswitch (Gd-II). It consists of two stem–loops forming a dimer upon ligand binding. Using extensive mo...

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Detalles Bibliográficos
Autores principales: Steuer, Jakob, Kukharenko, Oleksandra, Riedmiller, Kai, Hartig, Jörg S, Peter, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373139/
https://www.ncbi.nlm.nih.gov/pubmed/34233001
http://dx.doi.org/10.1093/nar/gkab592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373139/
https://www.ncbi.nlm.nih.gov/pubmed/34233001
http://dx.doi.org/10.1093/nar/gkab592

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