N(6)-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5

Alkbh5 catalyzes demethylation of the N(6)-methyladenosine (m(6)A), an epigenetic mark that controls several physiological processes including carcinogenesis and stem cell differentiation. The activity of Alkbh5 comprises two coupled reactions. The first reaction involves decarboxylation of α-ketogl...

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Detalles Bibliográficos
Autores principales: Purslow, Jeffrey A., Nguyen, Trang T., Khatiwada, Balabhadra, Singh, Aayushi, Venditti, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373141/
https://www.ncbi.nlm.nih.gov/pubmed/34407931
http://dx.doi.org/10.1126/sciadv.abi8215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373141/
https://www.ncbi.nlm.nih.gov/pubmed/34407931
http://dx.doi.org/10.1126/sciadv.abi8215

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