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N(6)-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5
Alkbh5 catalyzes demethylation of the N(6)-methyladenosine (m(6)A), an epigenetic mark that controls several physiological processes including carcinogenesis and stem cell differentiation. The activity of Alkbh5 comprises two coupled reactions. The first reaction involves decarboxylation of α-ketogl...
Autores principales: | Purslow, Jeffrey A., Nguyen, Trang T., Khatiwada, Balabhadra, Singh, Aayushi, Venditti, Vincenzo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373141/ https://www.ncbi.nlm.nih.gov/pubmed/34407931 http://dx.doi.org/10.1126/sciadv.abi8215 |
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