Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations

Microsatellite expansions are the cause of >20 neurological or developmental human disorders. Shortening expanded repeats using specific DNA endonucleases may be envisioned as a gene editing approach. Here, we measured the efficacy of several CRISPR–Cas nucleases to induce recombination within di...

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Detalles Bibliográficos
Autores principales: Poggi, Lucie, Emmenegger, Lisa, Descorps-Declère, Stéphane, Dumas, Bruno, Richard, Guy-Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373144/
https://www.ncbi.nlm.nih.gov/pubmed/34233005
http://dx.doi.org/10.1093/nar/gkab569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373144/
https://www.ncbi.nlm.nih.gov/pubmed/34233005
http://dx.doi.org/10.1093/nar/gkab569

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