Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse

TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis (ALS) cases, suggesting a central pathogenic role of this regulatory protein. Clarifying the molecular mechanism controlling TDP43 stability and subcellular location might provide important insights into ALS therapy. The ub...

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Detalles Bibliográficos
Autores principales: Ma, Pengcheng, Li, Yuwei, Wang, Huishan, Mao, Bingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373269/
https://www.ncbi.nlm.nih.gov/pubmed/33386850
http://dx.doi.org/10.1093/jmcb/mjaa072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373269/
https://www.ncbi.nlm.nih.gov/pubmed/33386850
http://dx.doi.org/10.1093/jmcb/mjaa072

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