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Knockdown of astrocytic Grin2a aggravates β‐amyloid‐induced memory and cognitive deficits through regulating nerve growth factor
Synapse degeneration correlates strongly with cognitive impairments in Alzheimer's disease (AD) patients. Soluble Amyloid‐beta (Aβ) oligomers are thought as the major trigger of synaptic malfunctions. Our earlier studies have demonstrated that Aβ oligomers interfere with synaptic function throu...
Autores principales: | Du, Zunshu, Song, Yizhi, Chen, Xinyue, Zhang, Wanning, Zhang, Guitao, Li, Hui, Chang, Lirong, Wu, Yan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373273/ https://www.ncbi.nlm.nih.gov/pubmed/34291567 http://dx.doi.org/10.1111/acel.13437 |
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