Cardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress

INTRODUCTION: Doxorubicin (Dox) is an effective anticancer agent; however, its cardiotoxicity remains a challenge. Dysfunction of intracellular calcium ion (Ca(2+)) is implicated in the process of Dox-induced cardiomyocyte apoptosis. Although store-operated Ca(2+) entry (SOCE) is suggested to be res...

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Detalles Bibliográficos
Autores principales: Zhu, Jiang, Zhang, Xia, Xie, Hong, Wang, Yuye, Zhang, Xiaoxiao, Lin, Zhaoheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373307/
https://www.ncbi.nlm.nih.gov/pubmed/34421306
http://dx.doi.org/10.2147/JIR.S304520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373307/
https://www.ncbi.nlm.nih.gov/pubmed/34421306
http://dx.doi.org/10.2147/JIR.S304520

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