Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction

The nuclear factor‐erythroid 2‐related factor‐2 (Nrf2), a major antioxidant transcription factor, is decreased in several age‐related diseases including age‐related macular degeneration (AMD), the most common cause of blindness among the elderly in western society. Since Nrf2’s mito‐protective respo...

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Detalles Bibliográficos
Autores principales: Cano, Marisol, Datta, Sayantan, Wang, Lei, Liu, Tongyun, Flores‐Bellver, Miguel, Sachdeva, Mira, Sinha, Debasish, Handa, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373343/
https://www.ncbi.nlm.nih.gov/pubmed/34313391
http://dx.doi.org/10.1111/acel.13444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373343/
https://www.ncbi.nlm.nih.gov/pubmed/34313391
http://dx.doi.org/10.1111/acel.13444

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