Cargando…

Notch1 haploinsufficiency in mice accelerates adipogenesis

Notch signaling has been recognized recently as a key regulator of metabolism. Here, we determined the role of Notch1 in adipogenesis in wild-type (WT) and Notch1 hetero-mutant (N1+/−) mice provided with 12-week normal or high-fat diet. Haploinsufficiency of Notch1 was associated with adipose tissue...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamaguchi, Kazutoshi, Hayashi, Motoharu, Uchida, Yasuhiro, Cheng, Xian Wu, Nakayama, Takayuki, Matsushita, Tadashi, Murohara, Toyoaki, Takeshita, Kyosuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373919/ https://www.ncbi.nlm.nih.gov/pubmed/34408185 http://dx.doi.org/10.1038/s41598-021-96017-z

Ejemplares similares

Indoxyl Sulfate-induced Vascular Calcification is mediated through Altered Notch Signaling Pathway in Vascular Smooth Muscle Cells
por: Yamaguchi, Kazutoshi, et al.
Publicado: (2020)

Angiotensin II Receptor Blocker Ameliorates Stress-Induced Adipose Tissue Inflammation and Insulin Resistance
por: Hayashi, Motoharu, et al.
Publicado: (2014)

Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
por: Yisireyili, Maimaiti, et al.
Publicado: (2017)

Recovery of Flow-Mediated Vasodilatation after Repetitive Measurements Is Involved in Early Vascular Impairment: Comparison with Indices of Vascular Tone
por: Inaba, Hatsumi, et al.
Publicado: (2014)

Stress Augments Insulin Resistance and Prothrombotic State: Role of Visceral Adipose-Derived Monocyte Chemoattractant Protein-1
por: Uchida, Yasuhiro, et al.
Publicado: (2012)

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals
por: Sawaguchi, Shogo, et al.
Publicado: (2017)

Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells
por: Yisireyili, Maimaiti, et al.
Publicado: (2017)

Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background
por: Koenig, Sara N., et al.
Publicado: (2015)

Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
por: Marinkovic, Milica, et al.
Publicado: (2019)

Notch pathway inhibitor DAPT accelerates in vitro proliferation and adipogenesis in infantile hemangioma stem cells
por: Xu, Xing, et al.
Publicado: (2021)

Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice
por: Guachalla, Luis Miguel, et al.
Publicado: (2009)

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice
por: Blackwood, Christopher A., et al.
Publicado: (2020)

Correction for: Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice
por: Guachalla, Luis Miguel, et al.
Publicado: (2019)

Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study
por: Furusawa, Kenji, et al.
Publicado: (2019)

Different rate-dependent responses between J waves and the notches on an epicardial local electrogram in a patient with idiopathic ventricular fibrillation
por: Kamikubo, Yosuke, et al.
Publicado: (2017)

Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells
por: Yisireyili, Maimaiti, et al.
Publicado: (2014)

Circulatory power and ventilatory power over time under goal-oriented sequential combination therapy for pulmonary arterial hypertension
por: Hirashiki, Akihiro, et al.
Publicado: (2017)

Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice
por: Nojima, Aika, et al.
Publicado: (2013)

Cardiopulmonary Exercise Testing as a Tool for Diagnosing Pulmonary Hypertension in Patients with Dilated Cardiomyopathy
por: Hirashiki, Akihiro, et al.
Publicado: (2016)

Sox9-Haploinsufficiency Causes Glucose Intolerance in Mice
por: Dubois, Claire L., et al.
Publicado: (2011)

Rai1 Haploinsufficiency Is Associated with Social Abnormalities in Mice
por: Rao, Nalini R., et al.
Publicado: (2017)

Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis
por: Hirata, Masayuki, et al.
Publicado: (2011)

Adipose-derived regenerative cells as a promising therapy for cardiovascular diseases: an overview
por: Yamaguchi, Shukuro, et al.
Publicado: (2022)

Elastin haploinsufficiency accelerates age-related structural and functional changes in the renal microvasculature and impairment of renal hemodynamics in female mice
por: Dixon, Alethia J., et al.
Publicado: (2023)

Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma
por: Buchanan, Rebecca A., et al.
Publicado: (2019)

Therapeutic Angiogenesis with Somatic Stem Cell Transplantation
por: Murohara, Toyoaki
Publicado: (2019)

Haploinsufficiency for Steroidogenic Factor 1 Affects Maternal Behavior in Mice
por: Spanic, Tanja, et al.
Publicado: (2016)

Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice
por: Sheppard, Sarah E., et al.
Publicado: (2023)

Maternal Obesity During Pregnancy and Lactation Influences Offspring Obesogenic Adipogenesis but Not Developmental Adipogenesis in Mice
por: Sellayah, Dyan, et al.
Publicado: (2019)

Mechanisms With Clinical Implications for Atrial Fibrillation–Associated Remodeling: Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker
por: Fujita, Masaya, et al.
Publicado: (2013)

Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression
por: Sachdeva, Jaspreet, et al.
Publicado: (2017)

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1
por: Matsushita, Kazuyuki, et al.
Publicado: (2014)

PTEN haploinsufficiency and hemangiosarcoma
Publicado: (2012)

FAD104, a regulator of adipogenesis, is a novel suppressor of TGF-β–mediated EMT in cervical cancer cells
por: Goto, Motoharu, et al.
Publicado: (2017)

Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A20
por: Toyofuku, Etsushi, et al.
Publicado: (2022)

Electrocardiogram characteristics of P wave associated with successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation: Significance of changes in P‐wave duration and notched P wave
por: Yanagisawa, Satoshi, et al.
Publicado: (2019)

Associations between proteinuria and cardiovascular risk factors among hypertensive patients in Andkhoy, Afghanistan
por: Shoaib Hamrah, Mohammad, et al.
Publicado: (2016)

Haploinsufficiency of Cyfip1 Produces Fragile X-Like Phenotypes in Mice
por: Bozdagi, Ozlem, et al.
Publicado: (2012)

Alk1 haploinsufficiency causes glomerular dysfunction and microalbuminuria in diabetic mice
por: Lora Gil, Cindy, et al.
Publicado: (2020)

Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin
por: Muellerleile, Julia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qe23l1pavcdm1calog9mj46l79