Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli

Most single point mutations destabilize folded proteins. Mutations that stabilize a protein typically only have a small effect and multiple mutations are often needed to substantially increase the stability. Multiple point mutations may act synergistically on the stability, and it is often not strai...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamborg, Louise, Granata, Daniele, Olsen, Johan G., Roche, Jennifer Virginia, Pedersen, Lasse Ebdrup, Nielsen, Alex Toftgaard, Lindorff-Larsen, Kresten, Teilum, Kaare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373930/
https://www.ncbi.nlm.nih.gov/pubmed/34408246
http://dx.doi.org/10.1038/s42003-021-02490-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373930/
https://www.ncbi.nlm.nih.gov/pubmed/34408246
http://dx.doi.org/10.1038/s42003-021-02490-7

Ejemplares similares