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Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli
Most single point mutations destabilize folded proteins. Mutations that stabilize a protein typically only have a small effect and multiple mutations are often needed to substantially increase the stability. Multiple point mutations may act synergistically on the stability, and it is often not strai...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373930/ https://www.ncbi.nlm.nih.gov/pubmed/34408246 http://dx.doi.org/10.1038/s42003-021-02490-7 |