Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations

Human families with chromosomal rearrangements at 2q31, where the human HOXD locus maps, display mesomelic dysplasia, a severe shortening and bending of the limb. In mice, the dominant Ulnaless inversion of the HoxD cluster produces a similar phenotype suggesting the same origin for these malformati...

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Detalles Bibliográficos
Autores principales: Bolt, Christopher Chase, Lopez-Delisle, Lucille, Mascrez, Bénédicte, Duboule, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373931/
https://www.ncbi.nlm.nih.gov/pubmed/34408147
http://dx.doi.org/10.1038/s41467-021-25330-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373931/
https://www.ncbi.nlm.nih.gov/pubmed/34408147
http://dx.doi.org/10.1038/s41467-021-25330-y

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