RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

DNA damage prompts a diverse range of alterations to the chromatin landscape. The RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K)13/15 (mUb-H2A), forming a binding module for DNA repair proteins. BRCA1 promotes homologous recombination (HR), in part, through...

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Detalles Bibliográficos
Autores principales: Krais, John J., Wang, Yifan, Patel, Pooja, Basu, Jayati, Bernhardy, Andrea J., Johnson, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373961/
https://www.ncbi.nlm.nih.gov/pubmed/34408138
http://dx.doi.org/10.1038/s41467-021-25346-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373961/
https://www.ncbi.nlm.nih.gov/pubmed/34408138
http://dx.doi.org/10.1038/s41467-021-25346-4

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