Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present crystallographic and solution structures of a deAMPylati...

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Detalles Bibliográficos
Autores principales: Perera, Luke A., Preissler, Steffen, Zaccai, Nathan R., Prévost, Sylvain, Devos, Juliette M., Haertlein, Michael, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373988/
https://www.ncbi.nlm.nih.gov/pubmed/34408154
http://dx.doi.org/10.1038/s41467-021-25076-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373988/
https://www.ncbi.nlm.nih.gov/pubmed/34408154
http://dx.doi.org/10.1038/s41467-021-25076-7

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