Development and validation of a hedgehog heparin-binding assay for high-throughput screening

Sonic hedgehog (Shh) is a morphogenic protein with critical roles in embryogenesis and the development of some cancers. Hence, identifying inhibitors of the Shh pathway is of great therapeutic value. Heparin and HSPGs act as crucial modulators of Shh activity. To identify molecules that antagonize S...

Descripción completa

Detalles Bibliográficos
Autores principales: Lamson, David R., Hughes, Mark A., Adcock, Audrey F., Smith, Ginger R., Williams, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374160/
https://www.ncbi.nlm.nih.gov/pubmed/34434730
http://dx.doi.org/10.1016/j.mex.2020.101207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374160/
https://www.ncbi.nlm.nih.gov/pubmed/34434730
http://dx.doi.org/10.1016/j.mex.2020.101207

Ejemplares similares