Complete preclinical platform for intravitreal chemotherapy drug discovery for retinoblastoma: Assessment of pharmacokinetics, toxicity and efficacy using a rabbit model

Current melphalan-based intravitreal chemotherapy regimens for retinoblastoma vitreous seeds are effective, but cause significant ocular toxicity. We describe protocols for each step of a drug discovery pipeline for preclinical development of novel drugs to maximize efficacy and minimize toxicity. T...

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Detalles Bibliográficos
Autores principales: Daniels, Anthony B., Pierce, Janene M., Chen, Sheau-chiann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374393/
https://www.ncbi.nlm.nih.gov/pubmed/34430259
http://dx.doi.org/10.1016/j.mex.2021.101358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374393/
https://www.ncbi.nlm.nih.gov/pubmed/34430259
http://dx.doi.org/10.1016/j.mex.2021.101358

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