Optimization and validation of a DYRK1A TR-FRET assay for high-throughput screening

Due to its role in brain development, the DYRK1A kinase (dual-specificity tyrosine phosphorylation-regulated kinase 1a) has been proposed as a drug target for Down syndrome, and diseases associated with neurodegeneration including Alzheimer's and Parkinson's. Other diseases in which DYRK1A...

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Detalles Bibliográficos
Autores principales: Tarpley, Michael, Caligan, Thomas B., Onyenwoke, Rob U., Williams, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374527/
https://www.ncbi.nlm.nih.gov/pubmed/34430279
http://dx.doi.org/10.1016/j.mex.2021.101383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374527/
https://www.ncbi.nlm.nih.gov/pubmed/34430279
http://dx.doi.org/10.1016/j.mex.2021.101383

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