Gene therapy with caspase-3 small interfering RNA-nanoparticles is neuroprotective after optic nerve damage

Apoptosis, a key mechanism of programmed cell death, is triggered by caspase-3 protein and lowering its levels with gene therapy may rescue cell death after central nervous system damage. We developed a novel, non-viral gene therapy to block caspase-3 gene expression using small interfering RNA (siR...

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Detalles Bibliográficos
Autores principales: Tawfik, Mohamed, Zhang, Xiwei, Grigartzik, Lisa, Heiduschka, Peter, Hintz, Werner, Henrich-Noack, Petra, van Wachem, Berend, Sabel, Bernhard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374570/
https://www.ncbi.nlm.nih.gov/pubmed/33907045
http://dx.doi.org/10.4103/1673-5374.313068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374570/
https://www.ncbi.nlm.nih.gov/pubmed/33907045
http://dx.doi.org/10.4103/1673-5374.313068

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