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Gene therapy with caspase-3 small interfering RNA-nanoparticles is neuroprotective after optic nerve damage
Apoptosis, a key mechanism of programmed cell death, is triggered by caspase-3 protein and lowering its levels with gene therapy may rescue cell death after central nervous system damage. We developed a novel, non-viral gene therapy to block caspase-3 gene expression using small interfering RNA (siR...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wolters Kluwer - Medknow
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374570/ https://www.ncbi.nlm.nih.gov/pubmed/33907045 http://dx.doi.org/10.4103/1673-5374.313068 |