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The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers
Long-lasting immunity depends on the generation of protective antibodies through the germinal center (GC) reaction. N(6)-methyladenosine (m(6)A) modification of mRNAs by METTL3 activity modulates transcript lifetime primarily through the function of m(6)A readers; however, the physiological role of...
Autores principales: | Grenov, Amalie C., Moss, Lihee, Edelheit, Sarit, Cordiner, Ross, Schmiedel, Dominik, Biram, Adi, Hanna, Jacob H., Jensen, Torben Heick, Schwartz, Schraga, Shulman, Ziv |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374864/ https://www.ncbi.nlm.nih.gov/pubmed/34402854 http://dx.doi.org/10.1084/jem.20210360 |
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