Increased gene expression and copy number of mutated bla(KPC) lead to high-level ceftazidime/avibactam resistance in Klebsiella pneumoniae

BACKGROUND: Resistance to ceftazidime-avibactam was reported, and it is important to investigate the mechanisms of ceftazidime/avibactam resistance in K. pneumoniae with mutations in bla(KPC). RESULTS: We report the mutated bla(KPC) is not the only mechanism related to CZA resistance, and investigat...

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Detalles Bibliográficos
Autores principales: Sun, Lingxiao, Li, Haibo, Wang, Qi, Liu, Yingmei, Cao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375111/
https://www.ncbi.nlm.nih.gov/pubmed/34412588
http://dx.doi.org/10.1186/s12866-021-02293-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375111/
https://www.ncbi.nlm.nih.gov/pubmed/34412588
http://dx.doi.org/10.1186/s12866-021-02293-0

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