Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus

Although considered effective treatment for many yeast fungi, the therapeutic efficacy of the echinocandin class of antifungals for invasive aspergillosis (IA) is limited. Recent studies suggest intense kinase- and phosphatase-mediated echinocandin adaptation in A. fumigatus. To identify A. fumigatu...

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Detalles Bibliográficos
Autores principales: Souza, Ana Camila Oliveira, Martin-Vicente, Adela, Nywening, Ashley V., Ge, Wenbo, Lowes, David J., Peters, Brian M., Fortwendel, Jarrod R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376064/
https://www.ncbi.nlm.nih.gov/pubmed/34370772
http://dx.doi.org/10.1371/journal.ppat.1009806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376064/
https://www.ncbi.nlm.nih.gov/pubmed/34370772
http://dx.doi.org/10.1371/journal.ppat.1009806

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