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Virtual clinical trial simulations for a novel KRAS(G12C) inhibitor (ASP2453) in non‐small cell lung cancer
KRAS is a small GTPase family protein that relays extracellular growth signals to cell nucleus. KRAS (G12C) mutations lead to constitutive proliferation signaling and are prevalent across human cancers. ASP2453 is a novel, highly potent, and selective inhibitor of KRAS (G12C). Although preclinical d...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376128/ https://www.ncbi.nlm.nih.gov/pubmed/34043291 http://dx.doi.org/10.1002/psp4.12661 |