Virtual clinical trial simulations for a novel KRAS(G12C) inhibitor (ASP2453) in non‐small cell lung cancer

KRAS is a small GTPase family protein that relays extracellular growth signals to cell nucleus. KRAS (G12C) mutations lead to constitutive proliferation signaling and are prevalent across human cancers. ASP2453 is a novel, highly potent, and selective inhibitor of KRAS (G12C). Although preclinical d...

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Detalles Bibliográficos
Autores principales: Sayama, Hiroyuki, Marcantonio, Diana, Nagashima, Takeyuki, Shimazaki, Masashi, Minematsu, Tsuyoshi, Apgar, Joshua F, Burke, John M., Wille, Lucia, Nagasaka, Yasuhisa, Kirouac, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376128/
https://www.ncbi.nlm.nih.gov/pubmed/34043291
http://dx.doi.org/10.1002/psp4.12661

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