Cargando…
Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes
Chronic infection with HCV is manifested by dysregulation of innate immune responses and impaired T cell function at multiple levels. These changes may impact susceptibility to other infections, responsiveness to antiviral therapies, vaccine responsiveness, and development of complications such as h...
Autores principales: | Burchill, Matthew A., Salomon, Matthew P., Golden-Mason, Lucy, Wieland, Amanda, Maretti-Mira, Ana C., Gale, Michael, Rosen, Hugo R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376199/ https://www.ncbi.nlm.nih.gov/pubmed/34370798 http://dx.doi.org/10.1371/journal.ppat.1009799 |
Ejemplares similares
-
Chronic HCV infection promotes cytotoxicity in antigen-specific CD8(+) T cells regardless of virus specificity
por: Maretti-Mira, Ana C., et al.
Publicado: (2023) -
Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy
por: Burchill, Matthew A., et al.
Publicado: (2017) -
Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis
por: Maretti-Mira, Ana C., et al.
Publicado: (2021) -
Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity
por: Maretti-Mira, Ana C., et al.
Publicado: (2023) -
Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH
por: Maretti-Mira, Ana C., et al.
Publicado: (2022)