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Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation

Insects depend on the innate immune response for defense against a wide array of pathogens. Central to Drosophila immunity are antimicrobial peptides (AMPs), released into circulation when pathogens trigger either of the two widely studied signal pathways, Toll or IMD. The Toll pathway responds to i...

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Detalles Bibliográficos
Autores principales: Tang, Ruijuan, Huang, Wuren, Guan, Jingmin, Liu, Qiuning, Beerntsen, Brenda T., Ling, Erjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376203/
https://www.ncbi.nlm.nih.gov/pubmed/34370736
http://dx.doi.org/10.1371/journal.pgen.1009718