Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice

Adeno-associated virus (AAV) transduction efficiency and tropism are conventionally determined by high expression of a fluorescent reporter gene. Emerging data has suggested that such conventional methods may underestimate AAV transduction for cells in which reporter expression from AAV vectors is u...

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Detalles Bibliográficos
Autores principales: Torregrosa, Tess, Lehman, Sydney, Hana, Sam, Marsh, Galina, Xu, Shanqin, Koszka, Kathryn, Mastrangelo, Nicole, McCampbell, Alexander, Henderson, Christopher E., Lo, Shih-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376643/
https://www.ncbi.nlm.nih.gov/pubmed/33612827
http://dx.doi.org/10.1038/s41434-021-00223-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376643/
https://www.ncbi.nlm.nih.gov/pubmed/33612827
http://dx.doi.org/10.1038/s41434-021-00223-3

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