FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis

Fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m(6)A) demethylase, participates in tumor progression and metastasis in many malignancies, but its role in colorectal cancer (CRC) is still unclear. Here, we found that FTO protein levels, but not RNA levels, were downregulated in...

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Detalles Bibliográficos
Autores principales: Ruan, Dan-Yun, Li, Ting, Wang, Ying-Nan, Meng, Qi, Li, Yang, Yu, Kai, Wang, Min, Lin, Jin-Fei, Luo, Li-Zhi, Wang, De-Shen, Lin, Jun-Zhong, Bai, Long, Liu, Ze-Xian, Zhao, Qi, Wu, Xiang-Yuan, Ju, Huai-Qiang, Xu, Rui-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376648/
https://www.ncbi.nlm.nih.gov/pubmed/34218271
http://dx.doi.org/10.1038/s41388-021-01916-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376648/
https://www.ncbi.nlm.nih.gov/pubmed/34218271
http://dx.doi.org/10.1038/s41388-021-01916-0

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