SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation

Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA and the subsequent induction of a multifaceted immune response. This involves sequence-specific cleavage of the target RNA and production of cyclic oligoadenylate (cOA) molecules. Here we report that an expose...

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Detalles Bibliográficos
Autores principales: Steens, Jurre A., Zhu, Yifan, Taylor, David W., Bravo, Jack P. K., Prinsen, Stijn H. P., Schoen, Cor D., Keijser, Bart J. F., Ossendrijver, Michel, Hofstra, L. Marije, Brouns, Stan J. J., Shinkai, Akeo, van der Oost, John, Staals, Raymond H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376896/
https://www.ncbi.nlm.nih.gov/pubmed/34413302
http://dx.doi.org/10.1038/s41467-021-25337-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376896/
https://www.ncbi.nlm.nih.gov/pubmed/34413302
http://dx.doi.org/10.1038/s41467-021-25337-5

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