Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNFα-antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failure

BACKGROUND: A feedforward pathological signaling loop generated by TNFα and IFN-γ synergy in the inflamed lung, driving CXCL-10 (IP-10) and CXCL-9 chemokine-mediated activated T-cell and monocyte/macrophage tissue recruitment, may define the inflammatory biology of lethal COVID-19 respiratory failur...

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Detalles Bibliográficos
Autores principales: Hachem, Hilal, Godara, Amandeep, Schroeder, Courtney, Fein, Daniel, Mann, Hashim, Lawlor, Christian, Marshall, Jill, Klein, Andreas, Poutsiaka, Debra, Breeze, Janis L., Joshi, Raghav, Mathew, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376916/
https://www.ncbi.nlm.nih.gov/pubmed/34457357
http://dx.doi.org/10.1017/cts.2021.805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376916/
https://www.ncbi.nlm.nih.gov/pubmed/34457357
http://dx.doi.org/10.1017/cts.2021.805

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