Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp

P-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among the active compounds, two of them significantly increased intracellular doxo...

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Detalles Bibliográficos
Autores principales: Laiolo, Jerónimo, Lanza, Priscila Ailin, Parravicini, Oscar, Barbieri, Cecilia, Insuasty, Daniel, Cobo, Justo, Vera, D. Mariano Adolfo, Enriz, Ricardo Daniel, Carpinella, Maria Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376931/
https://www.ncbi.nlm.nih.gov/pubmed/34413359
http://dx.doi.org/10.1038/s41598-021-96226-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376931/
https://www.ncbi.nlm.nih.gov/pubmed/34413359
http://dx.doi.org/10.1038/s41598-021-96226-6

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