Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice

Mouse models of genetic mitochondrial disorders are generally used to understand specific molecular defects and their biochemical consequences, but rarely to map compensatory changes allowing survival. Here we took advantage of the extraordinary mitochondrial resilience of hepatic Lrpprc knockout mi...

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Detalles Bibliográficos
Autores principales: Cuillerier, Alexanne, Ruiz, Matthieu, Daneault, Caroline, Forest, Anik, Rossi, Jenna, Vasam, Goutham, Cairns, George, Cadete, Virgilio, Des Rosiers, Christine, Burelle, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376967/
https://www.ncbi.nlm.nih.gov/pubmed/34413467
http://dx.doi.org/10.1038/s42003-021-02492-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376967/
https://www.ncbi.nlm.nih.gov/pubmed/34413467
http://dx.doi.org/10.1038/s42003-021-02492-5

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