DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

In vivo reprogramming provokes a wide range of cell fate conversion. Here, we discover that in vivo induction of higher levels of OSKM in mouse somatic cells leads to increased expression of primordial germ cell (PGC)-related genes and provokes genome-wide erasure of genomic imprinting, which takes...

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Detalles Bibliográficos
Autores principales: Taguchi, Jumpei, Shibata, Hirofumi, Kabata, Mio, Kato, Masaki, Fukuda, Kei, Tanaka, Akito, Ohta, Sho, Ukai, Tomoyo, Mitsunaga, Kanae, Yamada, Yosuke, Nagaoka, So I, Yamazawa, Sho, Ohnishi, Kotaro, Woltjen, Knut, Ushiku, Tetsuo, Ozawa, Manabu, Saitou, Mitinori, Shinkai, Yoichi, Yamamoto, Takuya, Yamada, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377058/
https://www.ncbi.nlm.nih.gov/pubmed/34413299
http://dx.doi.org/10.1038/s41467-021-25249-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377058/
https://www.ncbi.nlm.nih.gov/pubmed/34413299
http://dx.doi.org/10.1038/s41467-021-25249-4

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