Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8

This study evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of enpatoran (formerly named M5049), a new toll‐like receptor (TLR) 7 and 8 dual antagonist, and the effect of food on a single dose in healthy participants. In this sing...

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Detalles Bibliográficos
Autores principales: Port, Andreas, Shaw, Jamie V., Klopp‐Schulze, Lena, Bytyqi, Afrim, Vetter, Claudia, Hussey, Elizabeth, Mammasse, Nadra, Ona, Victor, Bachmann, Angelika, Strugala, Denis, Reh, Christian, Goteti, Kosalaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377444/
https://www.ncbi.nlm.nih.gov/pubmed/34414672
http://dx.doi.org/10.1002/prp2.842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377444/
https://www.ncbi.nlm.nih.gov/pubmed/34414672
http://dx.doi.org/10.1002/prp2.842

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