Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs

Serum protein interactions are evaluated during the drug development process since they determine the free drug concentration in blood and thereby can influence the drug's pharmacokinetic and pharmacodynamic properties. While the impact of serum proteins on the disposition of small molecules is...

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Detalles Bibliográficos
Autores principales: Agarwal, Saket, Allard, Ruth, Darcy, Justin, Chigas, Samantha, Gu, Yongli, Nguyen, Tuyen, Bond, Sarah, Chong, Saeho, Wu, Jing-Tao, Janas, Maja M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377513/
https://www.ncbi.nlm.nih.gov/pubmed/33861634
http://dx.doi.org/10.1089/nat.2020.0919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377513/
https://www.ncbi.nlm.nih.gov/pubmed/33861634
http://dx.doi.org/10.1089/nat.2020.0919

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