A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium

BACKGROUND & AIMS: Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden within colonic crypts exceeds a certain threshold that leads to clonal expansion and ultimately neoplastic transformation. Therefore, quantification of the fixation and subsequent expansion of so...

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Detalles Bibliográficos
Autores principales: Olpe, Cora, Khamis, Doran, Chukanova, Maria, Skoufou-Papoutsaki, Nefeli, Kemp, Richard, Marks, Kate, Tatton, Cerys, Lindskog, Cecilia, Nicholson, Anna, Brunton-Sim, Roxanne, Malhotra, Shalini, ten Hoopen, Rogier, Stanley, Rachael, Winton, Douglas J., Morrissey, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377717/
https://www.ncbi.nlm.nih.gov/pubmed/33895166
http://dx.doi.org/10.1053/j.gastro.2021.04.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377717/
https://www.ncbi.nlm.nih.gov/pubmed/33895166
http://dx.doi.org/10.1053/j.gastro.2021.04.035

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