Cargando…

Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

BACKGROUND: Liver cancer, mainly hepatocellular carcinoma, is one of the deadliest cancers worldwide and has a poor prognosis due to insufficient understanding of hepatocarcinogenesis. Previous studies have revealed that the mutations in PTEN and TP53 are the two most common genetic events in hepato...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Juanjuan, Lu, Chunjiao, Feng, Meilan, Dai, Lu, Wang, Maya, Qiu, Yang, Zheng, Huilu, Liu, Yao, Li, Li, Tang, Bo, Xu, Chuan, Wang, Yajun, Yang, Xiaojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377946/ https://www.ncbi.nlm.nih.gov/pubmed/34416907 http://dx.doi.org/10.1186/s13046-021-02061-y

Ejemplares similares

Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis
por: Zhou, Yi, et al.
Publicado: (2023)

Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish
por: Luo, Juanjuan, et al.
Publicado: (2020)

Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
por: Feng, Meilan, et al.
Publicado: (2022)

Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish
por: Lu, Jeng-Wei, et al.
Publicado: (2013)

CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice
por: Liu, Yongzhen, et al.
Publicado: (2017)

brca2 and tp53 Collaborate in Tumorigenesis in Zebrafish
por: Shive, Heather R., et al.
Publicado: (2014)

Repurposing auranofin to treat TP53-mutated or PTEN-deleted refractory B-cell lymphoma
por: Wang, Jeffrey, et al.
Publicado: (2019)

TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
por: Noel, Zsanett, et al.
Publicado: (2020)

Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish
por: Yan, Chuan, et al.
Publicado: (2015)

Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma
por: Wan, Huiying, et al.
Publicado: (2021)

73565 Defining tp53 tumor suppressor functions in zebrafish embryonal rhabdomyosarcoma
por: Baxi, Kunal, et al.
Publicado: (2021)

Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model
por: Yang, Wan-Yu, et al.
Publicado: (2019)

Effects of astragalus injection on different stages of early hepatocarcinogenesis in a two-stage hepatocarcinogenesis model using rats
por: Tang, Qian, et al.
Publicado: (2019)

Detection and Correlation of Single and Concomitant TP53, PTEN, and CDKN2A Alterations in Gliomas
por: Pessôa, Igor Andrade, et al.
Publicado: (2019)

TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
por: Wang, Haiwei, et al.
Publicado: (2022)

Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration
por: Shoffner, Adam, et al.
Publicado: (2020)

TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro
por: Singh, Sanjay K., et al.
Publicado: (2023)

Prevalence and spectrum of AKT1, PIK3CA, PTEN and TP53 somatic mutations in Chinese breast cancer patients
por: Li, Guoli, et al.
Publicado: (2018)

Mitigating the Risk of t-MNs Development: TP53 or Not TP53?
por: Tesio, Melania
Publicado: (2023)

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
por: Leroy, Bernard, et al.
Publicado: (2013)

TP53 and PTEN mutations were shared in concurrent germ cell tumor and acute megakaryoblastic leukemia
por: Akizuki, Keiichi, et al.
Publicado: (2020)

Thyroid cancer harboring PTEN and TP53 mutations: A peculiar molecular and clinical case report
por: Colombo, Carla, et al.
Publicado: (2022)

miR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis
por: Xia, Xiaohuan, et al.
Publicado: (2019)

Overexpression of Endothelin 1 Triggers Hepatocarcinogenesis in Zebrafish and Promotes Cell Proliferation and Migration through the AKT Pathway
por: Lu, Jeng-Wei, et al.
Publicado: (2014)

Self-Renewing Pten(-/-)TP53(-/-) Protospheres Produce Metastatic Adenocarcinoma Cell Lines with Multipotent Progenitor Activity
por: Abou-Kheir, Wassim, et al.
Publicado: (2011)

Synthetic lethality between TP53 and ENDOD1
por: Tang, Zizhi, et al.
Publicado: (2022)

Celecoxib attenuates hepatocellular proliferative capacity during hepatocarcinogenesis by modulating a PTEN/NF-κB/PRL-3 pathway
por: Zhang, Cong, et al.
Publicado: (2019)

Re-evaluation of the Carcinogenic Significance of Hepatitis B Virus Integration in Hepatocarcinogenesis
por: Jiang, Suzhen, et al.
Publicado: (2012)

Integrative analysis of TP53 mutations in lung adenocarcinoma for immunotherapies and prognosis
por: Li, He, et al.
Publicado: (2023)

Sex Reversal in Zebrafish fancl Mutants Is Caused by Tp53-Mediated Germ Cell Apoptosis
por: Rodríguez-Marí, Adriana, et al.
Publicado: (2010)

Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation
por: Sun, Lili, et al.
Publicado: (2015)

Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis
por: Gao, Lu, et al.
Publicado: (2016)

Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA
por: Li, Xuerui, et al.
Publicado: (2020)

TP53 inhibitor PFTα increases the sensitivity of arsenic trioxide in TP53 wildtype tumor cells
por: Wang, Haiwei, et al.
Publicado: (2022)

tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish
por: Ignatius, Myron S, et al.
Publicado: (2018)

ACTH-secreting pituitary carcinoma with TP53, NF1, ATRX and PTEN mutations Case report and review of the literature
por: Sumislawski, Piotr, et al.
Publicado: (2022)

FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations
por: Choi, Yuri, et al.
Publicado: (2022)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia
por: Lu, Charles, et al.
Publicado: (2016)

Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability
por: Tam, Benjamin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_itafhvvqis1tl01lrrc6d40csn