Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides

[Image: see text] The amyloid-β precursor protein (APP) undergoes proteolytic cleavage by α-, β-, and γ-secretases, to determine its fate in Alzheimer’s disease (AD) pathogenesis. Recent findings suggest a possible role of O-glycosylation in APP’s proteolytic processing. Therefore, we synthesized na...

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Detalles Bibliográficos
Autores principales: Singh, YashoNandini, Ormaza, David, Massetti, Alessandra, Minond, Dmitriy, Cudic, Maré
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378340/
https://www.ncbi.nlm.nih.gov/pubmed/34324289
http://dx.doi.org/10.1021/acschemneuro.1c00387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378340/
https://www.ncbi.nlm.nih.gov/pubmed/34324289
http://dx.doi.org/10.1021/acschemneuro.1c00387

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