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Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing
DNA methylation is an epigenetic process that controls DNA accessibility and serves as a transcriptomic switch when deposited at regulatory regions. The adequate functioning of this process is indispensable for tissue homeostasis and cell fate determination. Conversely, altered DNA methylation patte...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378768/ https://www.ncbi.nlm.nih.gov/pubmed/34434494 http://dx.doi.org/10.18632/oncotarget.28037 |