Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery–on–a–chip

A three-dimensional microengineered human coronary artery–on–a–chip was developed for investigation of the mechanism by which low and oscillatory shear stress (OSS) induces pro-atherogenic changes. Single-cell RNA sequencing revealed that OSS induced distinct changes in endothelial cells (ECs) inclu...

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Detalles Bibliográficos
Autores principales: Zhao, Peng, Yao, Qingzhou, Zhang, Pei-Jian, The, Erlinda, Zhai, Yufeng, Ao, Lihua, Jarrett, Michael J., Dinarello, Charles A., Fullerton, David A., Meng, Xianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378826/
https://www.ncbi.nlm.nih.gov/pubmed/34417174
http://dx.doi.org/10.1126/sciadv.abg1694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378826/
https://www.ncbi.nlm.nih.gov/pubmed/34417174
http://dx.doi.org/10.1126/sciadv.abg1694

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