Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

The role of compartmentalized signaling in primary cilia during tissue morphogenesis is not well understood. The cilia localized G protein-coupled receptor, Gpr161, represses hedgehog pathway via cAMP signaling. We engineered a knock-in at the Gpr161 locus in mice to generate a variant (Gpr161(mut1)...

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Detalles Bibliográficos
Autores principales: Hwang, Sun-Hee, Somatilaka, Bandarigoda N, White, Kevin, Mukhopadhyay, Saikat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378848/
https://www.ncbi.nlm.nih.gov/pubmed/34346313
http://dx.doi.org/10.7554/eLife.67121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378848/
https://www.ncbi.nlm.nih.gov/pubmed/34346313
http://dx.doi.org/10.7554/eLife.67121

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