New Peceol™/Span™ 60 Niosomes Coated with Chitosan for Candesartan Cilexetil: Perspective Increase in Absolute Bioavailability in Rats

PURPOSE: Candesartan cilexetil (CC), a prodrug of candesartan (CDT), is a class II BCS drug that suffers from poor oral bioavailability because of low aqueous solubility, P-gp efflux and first-pass metabolism. The absolute bioavailability reported for CC was only 15% and the methods to increase it r...

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Detalles Bibliográficos
Autores principales: AbuElfadl, Aya, Boughdady, Mariza, Meshali, Mahasen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378936/
https://www.ncbi.nlm.nih.gov/pubmed/34429601
http://dx.doi.org/10.2147/IJN.S324171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378936/
https://www.ncbi.nlm.nih.gov/pubmed/34429601
http://dx.doi.org/10.2147/IJN.S324171

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