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New Peceol™/Span™ 60 Niosomes Coated with Chitosan for Candesartan Cilexetil: Perspective Increase in Absolute Bioavailability in Rats

PURPOSE: Candesartan cilexetil (CC), a prodrug of candesartan (CDT), is a class II BCS drug that suffers from poor oral bioavailability because of low aqueous solubility, P-gp efflux and first-pass metabolism. The absolute bioavailability reported for CC was only 15% and the methods to increase it r...

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Detalles Bibliográficos
Autores principales:	AbuElfadl, Aya, Boughdady, Mariza, Meshali, Mahasen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378936/ https://www.ncbi.nlm.nih.gov/pubmed/34429601 http://dx.doi.org/10.2147/IJN.S324171

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